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PGA elicits minimal acute inflammatory reaction in tissues, which is followed by gradual encapsulation of the suture by fibrous connective tissue. Progressive loss of tensile strength and eventual absorption of PGA synthetic absorbable suture occurs by means of hydrolysis, where the polymer degrades to either glycolic acid or glycolic and lactic acids which are subsequently absorbed and metabolized by the body. Absorption begins as a loss of tensile strength without appreciable loss of mass. Implantation studies in animals indicate that PGA retains approximately 73% of its original tensile strength at two weeks post implantation, with approximately 33% remaining at three weeks. Absorption of PGA synthetic absorbable surgical suture is essentially complete between 60 and 90 days.
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